Neuroprotective effects of novel antiepileptic drug lacosamide via decreasing glial activation in the hippocampus of a gerbil model of ischemic stroke

Results The results showed that preand post-treatment with 25 mg/kg lacosamide significantly protected neuronal death from transient cerebral ischemic injury. Many H&E positive cells, NeuN-immunoreactive neurons and a few number of F-J B-positive cells were found in the stratum pyramidale of the CA1 region in the lacosamide-treated-ischemia-operated groups compared with those in the vehicle-treated-ischemia-operated group. In addition, the treatment with 25 mg/kg lacosamide markedly attenuated the activation of astrocytes and microglia in the ischemic CA1 region.